This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HTRA4-20-RE | 20 (40 μL) | 200 μL |  |
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| HTRA4-20-OR | 20 (40 μL) | 200 μL |  |
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| HTRA4-20-GO | 20 (40 μL) | 200 μL |  |
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| HTRA4-20-GR | 20 (40 μL) | 200 μL |  |
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| HTRA4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
Gene Symbol : HTRA4
Gene Name : HtrA serine peptidase 4
Chromosome : CHR 8: 389,741,48-389,886,61
Locus : 8p11.22
Alt. Genes : AKAP9
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