The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HSPB8-20-RE | 20 (40 μL) | 200 μL |  |
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| HSPB8-20-OR | 20 (40 μL) | 200 μL |  |
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| HSPB8-20-GO | 20 (40 μL) | 200 μL |  |
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| HSPB8-20-GR | 20 (40 μL) | 200 μL |  |
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| HSPB8-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Gene Symbol : HSPB8
Gene Name : Heat shock protein family B (small) member 8
Chromosome : CHR 12: 119,178,789-119,194,745
Locus : 12q24.23
Alt. Genes : LRPPRC
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