This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HMGA2-20-RE | 20 (40 μL) | 200 μL |  |
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| HMGA2-20-OR | 20 (40 μL) | 200 μL |  |
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| HMGA2-20-GO | 20 (40 μL) | 200 μL |  |
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| HMGA2-20-GR | 20 (40 μL) | 200 μL |  |
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| HMGA2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Symbol : HMGA2
Gene Name : High mobility group AT-hook 2
Chromosome : CHR 12: 658,244,59-659,662,90
Locus : 12q14.3
Alt. Genes : SLC25A15
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