This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HERC5-20-RE | 20 (40 μL) | 200 μL |  |
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| HERC5-20-OR | 20 (40 μL) | 200 μL |  |
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| HERC5-20-GO | 20 (40 μL) | 200 μL |  |
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| HERC5-20-GR | 20 (40 μL) | 200 μL |  |
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| HERC5-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]
Gene Symbol : HERC5
Gene Name : HECT and RLD domain containing E3 ubiquitin protein ligase 5
Chromosome : CHR 4: 884,566,03-885,061,69
Locus : 4q22.1
Alt. Genes : ZNF256
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