Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| HDAC3-20-RE | 20 (40 μL) | 200 μL |  |
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| HDAC3-20-OR | 20 (40 μL) | 200 μL |  |
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| HDAC3-20-GO | 20 (40 μL) | 200 μL |  |
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| HDAC3-20-GR | 20 (40 μL) | 200 μL |  |
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| HDAC3-20-AQ | 20 (40 μL) | 200 μL |  |
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Symbol : HDAC3
Gene Name : Histone deacetylase 3
Chromosome : CHR 5: 141,636,859-141,620,875
Locus : 5q31.3
Alt. Genes : OPTN
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