The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GRB2-20-RE | 20 (40 μL) | 200 μL |  |
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| GRB2-20-OR | 20 (40 μL) | 200 μL |  |
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| GRB2-20-GO | 20 (40 μL) | 200 μL |  |
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| GRB2-20-GR | 20 (40 μL) | 200 μL |  |
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| GRB2-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : GRB2
Gene Name : Growth factor receptor bound protein 2
Chromosome : CHR 17: 754,057,08-753,180,75
Locus : 17q25.1
Alt. Genes : SGK2
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