This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GRAP-20-RE | 20 (40 μL) | 200 μL |  |
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| GRAP-20-OR | 20 (40 μL) | 200 μL |  |
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| GRAP-20-GO | 20 (40 μL) | 200 μL |  |
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| GRAP-20-GR | 20 (40 μL) | 200 μL |  |
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| GRAP-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
Gene Symbol : GRAP
Gene Name : GRB2-related adaptor protein
Chromosome : CHR 17: 190,513,51-190,206,55
Locus : 17p11.2
Alt. Genes : RBM5
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