Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GCLC-20-RE | 20 (40 μL) | 200 μL |  |
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| GCLC-20-OR | 20 (40 μL) | 200 μL |  |
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| GCLC-20-GO | 20 (40 μL) | 200 μL |  |
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| GCLC-20-GR | 20 (40 μL) | 200 μL |  |
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| GCLC-20-AQ | 20 (40 μL) | 200 μL |  |
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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
Gene Symbol : GCLC
Gene Name : Glutamate-cysteine ligase catalytic subunit
Chromosome : CHR 6: 535,451,28-534,973,40
Locus : 6p12.1
Alt. Genes : FEM1B
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