This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| GAD2-20-RE | 20 (40 μL) | 200 μL |  |
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| GAD2-20-OR | 20 (40 μL) | 200 μL |  |
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| GAD2-20-GO | 20 (40 μL) | 200 μL |  |
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| GAD2-20-GR | 20 (40 μL) | 200 μL |  |
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| GAD2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Gene Symbol : GAD2
Gene Name : Glutamate decarboxylase 2
Chromosome : CHR 10: 262,163,06-263,045,61
Locus : 10p12.1
Alt. Genes : BCAP31
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