Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FZD7-20-RE | 20 (40 μL) | 200 μL |  |
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| FZD7-20-OR | 20 (40 μL) | 200 μL |  |
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| FZD7-20-GO | 20 (40 μL) | 200 μL |  |
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| FZD7-20-GR | 20 (40 μL) | 200 μL |  |
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| FZD7-20-AQ | 20 (40 μL) | 200 μL |  |
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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Gene Symbol : FZD7
Gene Name : Frizzled class receptor 7
Chromosome : CHR 2: 202,034,586-202,038,436
Locus : 2q33.1
Alt. Genes : PLXNC1
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