This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FRMPD2-20-RE | 20 (40 μL) | 200 μL |  |
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| FRMPD2-20-OR | 20 (40 μL) | 200 μL |  |
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| FRMPD2-20-GO | 20 (40 μL) | 200 μL |  |
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| FRMPD2-20-GR | 20 (40 μL) | 200 μL |  |
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| FRMPD2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2009]
Gene Symbol : FRMPD2
Gene Name : FERM and PDZ domain containing 2
Chromosome : CHR 10: 482,748,97-481,565,58
Locus : 10q11.22
Alt. Genes : LPAR6
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