Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FOXN1-20-RE | 20 (40 μL) | 200 μL |  |
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| FOXN1-20-OR | 20 (40 μL) | 200 μL |  |
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| FOXN1-20-GO | 20 (40 μL) | 200 μL |  |
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| FOXN1-20-GR | 20 (40 μL) | 200 μL |  |
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| FOXN1-20-AQ | 20 (40 μL) | 200 μL |  |
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Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]
Gene Symbol : FOXN1
Gene Name : Forkhead box N1
Chromosome : CHR 17: 285,062,10-285,388,99
Locus : 17q11.2
Alt. Genes : TRAP1
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