Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FMOD-20-RE | 20 (40 μL) | 200 μL |  |
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| FMOD-20-OR | 20 (40 μL) | 200 μL |  |
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| FMOD-20-GO | 20 (40 μL) | 200 μL |  |
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| FMOD-20-GR | 20 (40 μL) | 200 μL |  |
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| FMOD-20-AQ | 20 (40 μL) | 200 μL |  |
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Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Symbol : FMOD
Gene Name : Fibromodulin
Chromosome : CHR 1: 203,351,428-203,340,620
Locus : 1q32.1
Alt. Genes : LRPPRC
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