The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FHIT-20-RE | 20 (40 μL) | 200 μL |  |
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| FHIT-20-OR | 20 (40 μL) | 200 μL |  |
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| FHIT-20-GO | 20 (40 μL) | 200 μL |  |
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| FHIT-20-GR | 20 (40 μL) | 200 μL |  |
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| FHIT-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Symbol : FHIT
Gene Name : Fragile histidine triad
Chromosome : CHR 3: 612,514,73-597,472,77
Locus : 3p14.2
Alt. Genes : PREB
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