This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| FGFR1OP-20-RE | 20 (40 μL) | 200 μL |  |
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| FGFR1OP-20-OR | 20 (40 μL) | 200 μL |  |
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| FGFR1OP-20-GO | 20 (40 μL) | 200 μL |  |
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| FGFR1OP-20-GR | 20 (40 μL) | 200 μL |  |
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| FGFR1OP-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]
Gene Symbol : FGFR1OP
Gene Name : FGFR1 oncogene partner
Chromosome : CHR 6: 166,999,316-167,042,417
Locus : 6q27
Alt. Genes : FEM1B
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