This region includes a endogenous retrovirus long-terminal repeat (LTR)-derived sequence that binds SRY (sex determining region Y)-box 2 (SOX2) and functions as an enhancer of the proline dehydrogenase (oxidase) 1 (PRODH) gene. This sequence acts synergistically with a CG-rich region downstream of the transcription start site to promote expression of PRODH. Cytosine methylation of the LTR element but not the CG-region can block enhancer activity. The orthologous sequence in chimpanzee does not function as an enhancer, suggesting that regulation by this region is human-specific. [provided by RefSeq, Oct 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERVPRODH-20-RE | 20 (40 μL) | 200 μL |  |
Request Pricing |
| ERVPRODH-20-OR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| ERVPRODH-20-GO | 20 (40 μL) | 200 μL |  |
Request Pricing |
| ERVPRODH-20-GR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| ERVPRODH-20-AQ | 20 (40 μL) | 200 μL |  |
Request Pricing |
This region includes a endogenous retrovirus long-terminal repeat (LTR)-derived sequence that binds SRY (sex determining region Y)-box 2 (SOX2) and functions as an enhancer of the proline dehydrogenase (oxidase) 1 (PRODH) gene. This sequence acts synergistically with a CG-rich region downstream of the transcription start site to promote expression of PRODH. Cytosine methylation of the LTR element but not the CG-region can block enhancer activity. The orthologous sequence in chimpanzee does not function as an enhancer, suggesting that regulation by this region is human-specific. [provided by RefSeq, Oct 2015]
Gene Symbol : ERVPRODH
Gene Name : Human-specific endogenous retroviral insert (PRODH)
Chromosome : CHR 22: 0-0
Locus : 22q11.21
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.