Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERVFRD-1-20-RE | 20 (40 μL) | 200 μL |  |
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| ERVFRD-1-20-OR | 20 (40 μL) | 200 μL |  |
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| ERVFRD-1-20-GO | 20 (40 μL) | 200 μL |  |
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| ERVFRD-1-20-GR | 20 (40 μL) | 200 μL |  |
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| ERVFRD-1-20-AQ | 20 (40 μL) | 200 μL |  |
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Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]
Gene Symbol : ERVFRD-1
Gene Name : Endogenous retrovirus group FRD member 1, envelope
Chromosome : CHR 6: 111,118,37-111,024,88
Locus : 6p24.2
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