This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERLIN2-20-RE | 20 (40 μL) | 200 μL |  |
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| ERLIN2-20-OR | 20 (40 μL) | 200 μL |  |
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| ERLIN2-20-GO | 20 (40 μL) | 200 μL |  |
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| ERLIN2-20-GR | 20 (40 μL) | 200 μL |  |
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| ERLIN2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Symbol : ERLIN2
Gene Name : ER lipid raft associated 2
Chromosome : CHR 8: 377,365,78-377,578,00
Locus : 8p11.23
Alt. Genes : YAF2
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