The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ERCC2-20-RE | 20 (40 μL) | 200 μL |  |
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| ERCC2-20-OR | 20 (40 μL) | 200 μL |  |
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| ERCC2-20-GO | 20 (40 μL) | 200 μL |  |
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| ERCC2-20-GR | 20 (40 μL) | 200 μL |  |
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| ERCC2-20-AQ | 20 (40 μL) | 200 μL |  |
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The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Symbol : ERCC2
Gene Name : ERCC excision repair 2, TFIIH core complex helicase subunit
Chromosome : CHR 19: 453,706,46-453,498,36
Locus : 19q13.32
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