EMP2 FISH Probe

This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
EMP2-20-RE 20 (40 μL) 200 μL color Request Pricing
EMP2-20-OR 20 (40 μL) 200 μL color Request Pricing
EMP2-20-GO 20 (40 μL) 200 μL color Request Pricing
EMP2-20-GR 20 (40 μL) 200 μL color Request Pricing
EMP2-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]

Gene Details

Gene Symbol : EMP2

Gene Name : Epithelial membrane protein 2

Chromosome : CHR 16: 105,807,15-105,284,21

Locus : 16p13.13

Alt. Genes : MKRN3-AS1

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