This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| EEF1E1-20-RE | 20 (40 μL) | 200 μL |  |
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| EEF1E1-20-OR | 20 (40 μL) | 200 μL |  |
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| EEF1E1-20-GO | 20 (40 μL) | 200 μL |  |
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| EEF1E1-20-GR | 20 (40 μL) | 200 μL |  |
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| EEF1E1-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Gene Symbol : EEF1E1
Gene Name : Eukaryotic translation elongation factor 1 epsilon 1
Chromosome : CHR 6: 810,259,4-807,335,9
Locus : 6p24.3
Alt. Genes : KIF20A
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