The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DNAJB4-20-RE | 20 (40 μL) | 200 μL |  |
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| DNAJB4-20-OR | 20 (40 μL) | 200 μL |  |
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| DNAJB4-20-GO | 20 (40 μL) | 200 μL |  |
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| DNAJB4-20-GR | 20 (40 μL) | 200 μL |  |
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| DNAJB4-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Symbol : DNAJB4
Gene Name : DnaJ heat shock protein family (Hsp40) member B4
Chromosome : CHR 1: 779,791,57-780,179,63
Locus : 1p31.1
Alt. Genes : SGK2
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