Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| DENND1B-20-RE | 20 (40 μL) | 200 μL |  |
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| DENND1B-20-OR | 20 (40 μL) | 200 μL |  |
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| DENND1B-20-GO | 20 (40 μL) | 200 μL |  |
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| DENND1B-20-GR | 20 (40 μL) | 200 μL |  |
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| DENND1B-20-AQ | 20 (40 μL) | 200 μL |  |
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Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Gene Symbol : DENND1B
Gene Name : DENN domain containing 1B
Chromosome : CHR 1: 197,782,137-197,504,747
Locus : 1q31.3
Alt. Genes : FEM1B
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