DDIT3 FISH Probe

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
DDIT3-20-RE 20 (40 μL) 200 μL color Request Pricing
DDIT3-20-OR 20 (40 μL) 200 μL color Request Pricing
DDIT3-20-GO 20 (40 μL) 200 μL color Request Pricing
DDIT3-20-GR 20 (40 μL) 200 μL color Request Pricing
DDIT3-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

Gene Details

Gene Symbol : DDIT3

Gene Name : DNA damage inducible transcript 3

Chromosome : CHR 12: 575,205,16-575,165,87

Locus : 12q13.3

Alt. Genes : ABI2

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