This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CUL3-20-RE | 20 (40 μL) | 200 μL |  |
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| CUL3-20-OR | 20 (40 μL) | 200 μL |  |
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| CUL3-20-GO | 20 (40 μL) | 200 μL |  |
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| CUL3-20-GR | 20 (40 μL) | 200 μL |  |
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| CUL3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Symbol : CUL3
Gene Name : Cullin 3
Chromosome : CHR 2: 224,585,396-224,470,149
Locus : 2q36.2
Alt. Genes : OPTN
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