This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CPE-20-RE | 20 (40 μL) | 200 μL |  |
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| CPE-20-OR | 20 (40 μL) | 200 μL |  |
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| CPE-20-GO | 20 (40 μL) | 200 μL |  |
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| CPE-20-GR | 20 (40 μL) | 200 μL |  |
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| CPE-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]
Gene Symbol : CPE
Gene Name : Carboxypeptidase E
Chromosome : CHR 4: 165,378,941-165,498,546
Locus : 4q32.3
Alt. Genes : LRPPRC
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