CHRNG FISH Probe

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
CHRNG-20-RE 20 (40 μL) 200 μL color Request Pricing
CHRNG-20-OR 20 (40 μL) 200 μL color Request Pricing
CHRNG-20-GO 20 (40 μL) 200 μL color Request Pricing
CHRNG-20-GR 20 (40 μL) 200 μL color Request Pricing
CHRNG-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]

Gene Details

Gene Symbol : CHRNG

Gene Name : Cholinergic receptor nicotinic gamma subunit

Chromosome : CHR 2: 232,539,726-232,546,327

Locus : 2q37.1

Alt. Genes : OPTN

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