This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CHRNB4-20-RE | 20 (40 μL) | 200 μL |  |
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| CHRNB4-20-OR | 20 (40 μL) | 200 μL |  |
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| CHRNB4-20-GO | 20 (40 μL) | 200 μL |  |
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| CHRNB4-20-GR | 20 (40 μL) | 200 μL |  |
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| CHRNB4-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]
Gene Symbol : CHRNB4
Gene Name : Cholinergic receptor nicotinic beta 4 subunit
Chromosome : CHR 15: 786,555,85-786,232,81
Locus : 15q25.1
Alt. Genes : LINC01587
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