The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CFL1-20-RE | 20 (40 μL) | 200 μL |  |
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| CFL1-20-OR | 20 (40 μL) | 200 μL |  |
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| CFL1-20-GO | 20 (40 μL) | 200 μL |  |
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| CFL1-20-GR | 20 (40 μL) | 200 μL |  |
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| CFL1-20-AQ | 20 (40 μL) | 200 μL |  |
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The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
Gene Symbol : CFL1
Gene Name : Cofilin 1
Chromosome : CHR 11: 658,583,32-658,548,10
Locus : 11q13.1
Alt. Genes : CFM1
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