This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CDKN1C-20-RE | 20 (40 μL) | 200 μL |  |
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| CDKN1C-20-OR | 20 (40 μL) | 200 μL |  |
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| CDKN1C-20-GO | 20 (40 μL) | 200 μL |  |
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| CDKN1C-20-GR | 20 (40 μL) | 200 μL |  |
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| CDKN1C-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Gene Symbol : CDKN1C
Gene Name : Cyclin dependent kinase inhibitor 1C
Chromosome : CHR 11: 288,580,3-288,321,7
Locus : 11p15.4
Alt. Genes : HNRNPR
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