This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CCDC88A-20-RE | 20 (40 μL) | 200 μL |  |
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| CCDC88A-20-OR | 20 (40 μL) | 200 μL |  |
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| CCDC88A-20-GO | 20 (40 μL) | 200 μL |  |
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| CCDC88A-20-GR | 20 (40 μL) | 200 μL |  |
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| CCDC88A-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Symbol : CCDC88A
Gene Name : Coiled-coil domain containing 88A
Chromosome : CHR 2: 554,199,20-552,878,16
Locus : 2p16.1
Alt. Genes : HIPK3
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