This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CBFA2T3-20-RE | 20 (40 μL) | 200 μL |  |
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| CBFA2T3-20-OR | 20 (40 μL) | 200 μL |  |
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| CBFA2T3-20-GO | 20 (40 μL) | 200 μL |  |
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| CBFA2T3-20-GR | 20 (40 μL) | 200 μL |  |
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| CBFA2T3-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Gene Symbol : CBFA2T3
Gene Name : CBFA2/RUNX1 translocation partner 3
Chromosome : CHR 16: 889,771,97-888,748,54
Locus : 16q24.3
Alt. Genes : ZNF263
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