Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CAPN3-20-RE | 20 (40 μL) | 200 μL |  |
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| CAPN3-20-OR | 20 (40 μL) | 200 μL |  |
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| CAPN3-20-GO | 20 (40 μL) | 200 μL |  |
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| CAPN3-20-GR | 20 (40 μL) | 200 μL |  |
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| CAPN3-20-AQ | 20 (40 μL) | 200 μL |  |
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Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Gene Symbol : CAPN3
Gene Name : Calpain 3
Chromosome : CHR 15: 423,594,99-424,123,16
Locus : 15q15.1
Alt. Genes : LRPPRC
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