The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| CAMLG-20-RE | 20 (40 μL) | 200 μL |  |
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| CAMLG-20-OR | 20 (40 μL) | 200 μL |  |
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| CAMLG-20-GO | 20 (40 μL) | 200 μL |  |
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| CAMLG-20-GR | 20 (40 μL) | 200 μL |  |
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| CAMLG-20-AQ | 20 (40 μL) | 200 μL |  |
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The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Gene Symbol : CAMLG
Gene Name : Calcium modulating ligand
Chromosome : CHR 5: 134,737,926-134,752,159
Locus : 5q31.1
Alt. Genes : ENAM
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