BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BPNT1-20-RE | 20 (40 μL) | 200 μL |  |
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| BPNT1-20-OR | 20 (40 μL) | 200 μL |  |
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| BPNT1-20-GO | 20 (40 μL) | 200 μL |  |
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| BPNT1-20-GR | 20 (40 μL) | 200 μL |  |
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| BPNT1-20-AQ | 20 (40 μL) | 200 μL |  |
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BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
Gene Symbol : BPNT1
Gene Name : 3'(2'), 5'-bisphosphate nucleotidase 1
Chromosome : CHR 1: 220,089,915-220,057,481
Locus : 1q41
Alt. Genes : KIF20A
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