This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BMP2-20-RE | 20 (40 μL) | 200 μL |  |
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| BMP2-20-OR | 20 (40 μL) | 200 μL |  |
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| BMP2-20-GO | 20 (40 μL) | 200 μL |  |
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| BMP2-20-GR | 20 (40 μL) | 200 μL |  |
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| BMP2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Gene Symbol : BMP2
Gene Name : Bone morphogenetic protein 2
Chromosome : CHR 20: 676,769,9-678,027,9
Locus : 20p12.3
Alt. Genes : CTDSP2
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