This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BID-20-RE | 20 (40 μL) | 200 μL |  |
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| BID-20-OR | 20 (40 μL) | 200 μL |  |
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| BID-20-GO | 20 (40 μL) | 200 μL |  |
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| BID-20-GR | 20 (40 μL) | 200 μL |  |
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| BID-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Gene Symbol : BID
Gene Name : BH3 interacting domain death agonist
Chromosome : CHR 22: 177,746,64-177,341,39
Locus : 22q11.21
Alt. Genes : HIPK3
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