This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| BCL2L2-20-RE | 20 (40 μL) | 200 μL |  |
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| BCL2L2-20-OR | 20 (40 μL) | 200 μL |  |
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| BCL2L2-20-GO | 20 (40 μL) | 200 μL |  |
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| BCL2L2-20-GR | 20 (40 μL) | 200 μL |  |
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| BCL2L2-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
Gene Symbol : BCL2L2
Gene Name : BCL2 like 2
Chromosome : CHR 14: 233,067,61-233,117,58
Locus : 14q11.2
Alt. Genes : LILRB2
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