BCL2L1 FISH Probe

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]


Gene Details
SKU Test Kits Buffer Dye Color Order Now
BCL2L1-20-RE 20 (40 μL) 200 μL color Request Pricing
BCL2L1-20-OR 20 (40 μL) 200 μL color Request Pricing
BCL2L1-20-GO 20 (40 μL) 200 μL color Request Pricing
BCL2L1-20-GR 20 (40 μL) 200 μL color Request Pricing
BCL2L1-20-AQ 20 (40 μL) 200 μL color Request Pricing

Gene Summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]

Gene Details

Gene Symbol : BCL2L1

Gene Name : BCL2 like 1

Chromosome : CHR 20: 317,239,98-316,644,51

Locus : 20q11.21

Alt. Genes : SUGP2

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