This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ASPN-20-RE | 20 (40 μL) | 200 μL |  |
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| ASPN-20-OR | 20 (40 μL) | 200 μL |  |
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| ASPN-20-GO | 20 (40 μL) | 200 μL |  |
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| ASPN-20-GR | 20 (40 μL) | 200 μL |  |
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| ASPN-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014]
Gene Symbol : ASPN
Gene Name : Asporin
Chromosome : CHR 9: 924,825,61-924,562,04
Locus : 9q22.31
Alt. Genes : LRPPRC
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