This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ASPM-20-RE | 20 (40 μL) | 200 μL |  |
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| ASPM-20-OR | 20 (40 μL) | 200 μL |  |
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| ASPM-20-GO | 20 (40 μL) | 200 μL |  |
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| ASPM-20-GR | 20 (40 μL) | 200 μL |  |
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| ASPM-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Gene Symbol : ASPM
Gene Name : Abnormal spindle microtubule assembly
Chromosome : CHR 1: 197,146,693-197,084,126
Locus : 1q31.3
Alt. Genes : OPTN
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