Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APRT-20-RE | 20 (40 μL) | 200 μL |  |
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| APRT-20-OR | 20 (40 μL) | 200 μL |  |
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| APRT-20-GO | 20 (40 μL) | 200 μL |  |
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| APRT-20-GR | 20 (40 μL) | 200 μL |  |
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| APRT-20-AQ | 20 (40 μL) | 200 μL |  |
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Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Symbol : APRT
Gene Name : Adenine phosphoribosyltransferase
Chromosome : CHR 16: 888,119,33-888,094,68
Locus : 16q24.3
Alt. Genes : HIPK3
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