This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APC-20-RE | 20 (40 μL) | 200 μL |  |
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| APC-20-OR | 20 (40 μL) | 200 μL |  |
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| APC-20-GO | 20 (40 μL) | 200 μL |  |
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| APC-20-GR | 20 (40 μL) | 200 μL |  |
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| APC-20-AQ | 20 (40 μL) | 200 μL |  |
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This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
Gene Symbol : APC
Gene Name : APC, WNT signaling pathway regulator
Chromosome : CHR 5: 112,707,504-112,846,238
Locus : 5q22.2
Alt. Genes : OPTN
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