This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| APAF1-20-RE | 20 (40 μL) | 200 μL |  |
Request Pricing |
| APAF1-20-OR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| APAF1-20-GO | 20 (40 μL) | 200 μL |  |
Request Pricing |
| APAF1-20-GR | 20 (40 μL) | 200 μL |  |
Request Pricing |
| APAF1-20-AQ | 20 (40 μL) | 200 μL |  |
Request Pricing |
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Symbol : APAF1
Gene Name : Apoptotic peptidase activating factor 1
Chromosome : CHR 12: 986,451,40-987,354,32
Locus : 12q23.1
Alt. Genes : LRPPRC
Lorem Ipsum is simply dummy text of the printing and typesetting industry.
Lorem Ipsum is simply dummy text of the printing and typesetting industry.