Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| A1CF-20-RE | 20 (40 μL) | 200 μL |  |
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| A1CF-20-OR | 20 (40 μL) | 200 μL |  |
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| A1CF-20-GO | 20 (40 μL) | 200 μL |  |
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| A1CF-20-GR | 20 (40 μL) | 200 μL |  |
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| A1CF-20-AQ | 20 (40 μL) | 200 μL |  |
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Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Gene Symbol : A1CF
Gene Name : APOBEC1 complementation factor
Chromosome : CHR 10: 508,856,80-507,994,08
Locus : 10q11.23
Alt. Genes : RAD50
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