VAV1 Summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

VAV1 Details

Gene Symbol : VAV1

Gene Name : Vav guanine nucleotide exchange factor 1

Chromosome : CHR 19: 677,266,7-685,736,5

Locus : 19p13.3

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ZNF823 Details

Gene Symbol : ZNF823

Gene Name : Zinc finger protein 823

Chromosome : CHR 19: 117,390,08-117,212,64

Locus : 19p13.2

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