TGFBRAP1 Summary

This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]

TGFBRAP1 Details

Gene Symbol : TGFBRAP1

Gene Name : Transforming growth factor beta receptor associated protein 1

Chromosome : CHR 2: 105,329,713-105,249,403

Locus : 2q12.1-q12.2

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DPP10 Summary

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

DPP10 Details

Gene Symbol : DPP10

Gene Name : Dipeptidyl peptidase like 10

Chromosome : CHR 2: 114,442,357-115,845,751

Locus : 2q14.1

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