NTRK1 Summary

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

NTRK1 Details

Gene Symbol : NTRK1

Gene Name : Neurotrophic receptor tyrosine kinase 1

Chromosome : CHR 1: 156,815,749-156,881,849

Locus : 1q23.1

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TFG Summary

There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

TFG Details

Gene Symbol : TFG

Gene Name : TRK-fused gene

Chromosome : CHR 3: 100,709,283-100,748,966

Locus : 3q12.2

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