ABCG1 Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]

ABCG1 Details

Gene Symbol : ABCG1

Gene Name : ATP binding cassette subfamily G member 1

Chromosome : CHR 21: 421,996,88-423,043,88

Locus : 21q22.3

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BACE2 Summary

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

BACE2 Details

Gene Symbol : BACE2

Gene Name : Beta-site APP-cleaving enzyme 2

Chromosome : CHR 21: 411,678,00-412,825,33

Locus : 21q22.2-q22.3

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