ABCA12 Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

ABCA12 Details

Gene Symbol : ABCA12

Gene Name : ATP binding cassette subfamily A member 12

Chromosome : CHR 2: 215,138,590-214,931,541

Locus : 2q35

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SGPP2 Summary

The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

SGPP2 Details

Gene Symbol : SGPP2

Gene Name : Sphingosine-1-phosphate phosphatase 2

Chromosome : CHR 2: 222,424,051-222,562,621

Locus : 2q36.1

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